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Stavudine and viramune can be co-administered without dose adjustments.

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Saquinavir/ritonavir and Viramune can be co-administered without dose adjustments.

Indicated for treatment of HIV-1 infection in combination with other antiretroviralsalso used for prevention of maternal-fetal HIV transmission in women with no prior antiretroviral treatment.

A clinically not relevant increase in the apparent clearance of nevirapineby 9compared to historical data was reported.

Nevirapine metabolitesStudies using human liver microsomes indicated that the formation of nevirapine hydroxylated metabolites was not affected by the presence of dapsonerifabutinrifampicinand trimethoprim/sulfamethoxazoleKetoconazole and erythromycin significantly inhibited the formation of nevirapine hydroxylated metabolites.

Because of the risk of increased exposure to Viramunecaution should be exercised if the medicinal products are given concomitantly and patients should be monitored closely.

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