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Acute interstitial nephritis has been observed in patients taking PPIs including Protonix I.VAcute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reactionDiscontinue Protonix I.Vif acute interstitial nephritis developssee Contraindications4

Cutaneous lupus erythematosusCLEand systemic lupus erythematosusSLEhave been reported in patients taking PPIsincluding pantoprazole sodiumThese events have occurred as both new onset and an exacerbation of existing autoimmune diseaseThe majority of PPI-induced lupus erythematous cases were CLE.

The reconstituted solution may be stored for up to 24 hours at room temperature prior to intravenous infusion and does not need to be protected from light.

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