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In one controlled study of 175 patients, transient drowsiness was observed in 63 of those receiving lioresal compared to 36 of those in the placebo group.

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Abrupt discontinuation of intrathecal baclofenregardless of the causehas resulted in sequelae that include high feveraltered mental statusexaggerated rebound spasticityand muscle rigiditythat in rare cases has advanced to rhabdomyolysismultiple organ-system failure and death.

Pharmacodynamics of LIORESAL INTRATHECAL Intrathecal BolusAdult PatientsThe onset of action is generally one-half hour Alesse sale to one hour after an intrathecal bolusPeak spasmolytic effect is seen at approximately four hours after dosing and effects may last four to eight hoursOnsetpeak responseand duration of action may vary with individual patients depending on the dose and severity of symptoms.

Take this medication by mouth with or without food as directed by your doctorusually 3 times a dayTo reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.

Adverse experiences reported during all U.Sstudiesboth controlled and uncontrolledare shown in the following tableEight of 474 patients who received chronic infusion via implanted pumps had adverse experiences which led to a discontinuation of long term treatment in the preand post-marketing studies.

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