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Levothyroxineat doses individualized according to patient responseis effective as replacement or supplemental therapy in hypothyroidism of any etiologyexcept transient hypothyroidism during the recovery phase of subacute thyroiditis.

Infants with congenital hypothyroidism appear to be at increased risk for other congenital anomalieswith cardiovascular anomaliespulmonary stenosisatrial septal defectand ventricular septal defectbeing the most common association.

Many drugs affect thyroid hormone pharmacokinetics and metabolisme.gabsorptionsynthesissecretioncatabolismprotein bindingand target tissue responseand may alter the therapeutic response to SYNTHROIDIn additionthyroid hormones and thyroid status have varied effects on the pharmacokinetics and actions of other drugsA listing of drug-thyroidal axis interactions is contained in Table 2.

Some side effects of levothyroxine may occur that usually do not need medical attentionThese side effects may go away during treatment as your body adjusts to the medicineAlsoyour health care professional may be able to tell you about ways to prevent or reduce some of these side effectsCheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

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tsh directly influences the whole process of iodine trapping and thyroid hormone production so use of synthroid directly affects how the body metabolizes iodine.

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