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A study in six healthy volunteers has shown a significant increase in peak cardizem plasma levels 58 and area-under-the-curve 53 after a 1 week course of cimetidine at 1200 mg per day and a single dose of cardizem 60 mg.

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Grapefruit and grapefruit juice may interact with diltiazem and lead to potentially dangerous effectsDiscuss the use of grapefruit products with your doctor.

These medicines help most people with anginaand Cardizem CD will help control most people’s blood pressurebut they may have unwanted effects in a few people.

Diltiazem is an inhibitor of CYP3A4 and has been shown to increase significantly the AUC of some statinsThe risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4 may be increased with concomitant use of diltiazemWhen possibleuse a non-CYP3A4-metabolized statin together with diltiazemotherwisedose adjustments for both diltiazem and the statin should be considered along with close monitoring for signs and symptoms of any statin related adverse events.

Before having surgerytell your doctor or dentist that you are taking this medication.

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