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Methylprednisolone acetatea slightly soluble ester of methylprednisoloneis capable of producing a more prolonged local anti-inflammatory effect than equimolar doses of hydrocortisone acetateFollowing intrasynovial injectionrelief from pain may be experienced within 12 to 24 hoursThe duration of relief variesbut averages three to four weekswith a range of one to five or more weeksInjections of methylprednisolone acetate have been well toleratedIntrasynovialintra-articularinjections may occasionally result in an increased localized inflammatory response.

NoteThis document contains side effect information about methylprednisoloneSome of the dosage forms listed on this page may not apply to the brand name Medrol.

With therapeutically equivalent dosesthe likelihood of occurrence of troublesome side effects is less with methylprednisolone than with prednisolonemoreoverside effects actually have been conspicuously absent during clinical trials with MEDROL Tablets in dogs and catsHowevermethylprednisolone is similar to prednisolone in regard to kinds of side effects and metabolic alterations to be anticipated when treatment is intensive or prolongedIn animal patients with diabetes mellitususe of methylprednisolone may be associated with an increase in the insulin requirementNegative nitrogen balance may occurparticularly in animals that require protracted maintenance therapymeasures to counteract persistent nitrogen loss include a high protein intake and the administration when indicatedof a suitable anabolic agentExcessive loss of potassiumlike excessive retention of sodiumis not likely to be induced by effective maintenance doses of MEDROLHoweverthese effects should be kept in mind and the usual regulatory measures employed as indicatedEcchymotic manifestationswhile not noted during the clinical evaluation in dogs and catsmay occurIf such reactions do occur and are seriousreduction in dosage or discontinuance of methylprednisolone therapy may be indicatedConcurrent use of daily oral supplements of ascorbic acid may be of value in helping to control ecchymotic tendencies.

Frequency not reportedAbdominal distentionnauseapancreatitispeptic ulcerperforation of the small and large intestineulcerative esophagitisgastric hemorrhagevomitingabdominal paindiarrheadyspepsianauseaRef]

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