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Drospirenone; ethinyl estradiol; levomefolate major indinavir decreases the metabolism of oral contraceptives and non-oral combination contraceptives; the auc for ethinyl estradiol and norethindrone increased by 24 -17 and 26 -14 , respectively, when coadministered with indinavir.

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Initiation of CRIXIVANa CYP3A inhibitorin patients receiving medications metabolized by CYP3A or initiation of medications metabolized by CYP3A in patients already receiving CRIXIVANmay increase plasma concentrations of medications metabolized by CYP3AInitiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of CRIXIVANrespectivelyThese interactions may lead to:

Because of the complex regimens and side effects associated with the use of indinavirthis drug is rarely used in Canada and other high-income kegunaan obat levofloxacin, unisom in singapore. countriesStillif indinavir is prescribed in Canadahere is some information.

Patients with hemophiliaThere have been reports of spontaneous bleeding in patients with hemophilia A and B treated with protease inhibitorsIn some patientsadditional factor VIII was requiredIn many of the reported casestreatment with protease inhibitors was continued or restartedA causal relationship between protease inhibitor therapy and these episodes has not been establishedSee ADVERSE REACTIONSPost-Marketing Experience

Initiation of CRIXIVANa CYP3A inhibitorin patients receiving medications metabolized by CYP3A or initiation of medications metabolized by CYP3A in patients already receiving CRIXIVANmay increase plasma concentrations of medications metabolized by CYP3AInitiation of medications that inhibit or induce CYP3A may increase or decrease concentrations of CRIXIVANrespectivelyThese interactions may lead to:

CRIXIVAN may interact with some drugsthereforepatients should be advised to report to their doctor the use of any other prescriptionnon-prescription medication or herbal productsparticularly StJohn’s wort.

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indinavir may interfere with the metabolism of cyp3a4 substrates, like bepridil, and caution is warranted with coadministration.

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