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Treatment should be initiated as an adjunct to diet and exercise to lower the blood glucose in relation to meals.

The following substances may enhance and/or prolong the hypoglycaemic effect of repaglinideGemfibrozilclarithromycinitraconazoleketokonazoletrimethoprimciclosporindeferasiroxclopidogrelother antidiabetic substancesmonoamine oxidase inhibitorsMAOInon selective beta blocking substancesangiotensin converting enzymeACEinhibitorssalicylatesNSAIDsoctreotidealcoholand anabolic steroids.

The following substances may reduce the hypoglycaemic effect of repaglinide:

Repaglinide is indicated in adults with type 2 diabetes mellitus whose hyperglycaemia can no longer be controlled satisfactorily by dietweight reduction and exerciseRepaglinide is also indicated in combination with metformin in adults with type 2 diabetes mellitus who are not satisfactorily controlled on metformin alone.

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