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Ezetimibe does not inhibit cholesterol synthesis in the liveror increase bile acid excretionInsteadezetimibe localizes at the brush border of the small intestine and inhibits the absorption of cholesterolleading to a decrease in the delivery of intestinal cholesterol to the liverThis causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the bloodthis distinct mechanism is complementary to that of statins and of fenofibratesee Clinical Studies

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